Let me start with the highlight, with your permission. In a recent study, it was proven according to the most advanced scientific standards that HGH therapy reverses aging. You can find the study here: Pubmed Ncbi Nlm
Now, let’s delve into this to understand the background, the details, the significance, and what each of us can take from it.
Understanding HGH
Human Growth Hormone (HGH) is the primary hormone responsible for the growth and regeneration of various tissues in our body throughout our lifetime. From birth until adolescence, it drives the linear growth of our skeleton and other tissues and organs. In adults, it maintains a healthy metabolism and supports tissue regeneration.
Almost every tissue in our body has HGH receptors, meaning they are directly affected by HGH. Some of HGH’s anabolic (tissue growth) effects are direct, while others are mediated through other factors. HGH is responsible for the secretion of different growth factors:
- Systemically: HGH triggers the secretion of IGF-1 from target tissues like the liver. IGF-1 is considered the anabolic mediator of many HGH effects.
- Locally: HGH causes the secretion of growth factors in various target tissues, with autocrine or paracrine effects (these growth factors affect the organ that secretes them or its nearby area).
HGH, Metabolism, and the Immune System
HGH plays a pivotal role in metabolism and interacts with various glands, such as the pancreas and thyroid. It also has significant effects on the immune system, as highlighted by the study mentioned above.
HGH as an Anti-Aging Panacea or the Curse of IGF-1?
HGH secretion declines with age, affecting all the mentioned systems. For decades, many have considered HGH an anti-aging panacea and used it anecdotally to reverse aging. However, HGH has never been approved for therapeutic treatment in aging, and no scientific literature has supported these claims. Recently, some anti-aging approaches based on animal studies suggested that high IGF-1 levels, which are increased by HGH, are associated with shorter lifespans. This led to the notion that HGH might be counterproductive as an anti-aging agent.

So how do we measure the reversal of aging?
Many of you are familiar with the concept of chronological age vs. biological age, or simply how well (or poorly) our body is functioning relative to our actual calendar age. However, fewer might be familiar with the concept of epigenetic clocks. Let’s elaborate a bit: “epi” in Latin means “above,” so epigenetic describes how our body expresses the genetic code we inherited, or in other words, how the layer above our DNA interacts with it. For example, two identical twins may have nearly identical DNA, but if one smokes regularly and the other doesn’t, the manner in which the layer above their DNA interacts with the “same” DNA is altered, leading to different biological ages despite identical calendar ages. Scientists have developed various epigenetic clocks based on different factors that provide accurate indications of our biological age. The most significant of these is the GrimAge predictor, which provides a quite accurate indication of morbidity and mortality.
How does this study track age reversal, and what was it designed to do?
The study is named TRIIM (Thymus Regeneration, Immunorestoration, and Insulin Mitigation), and we’ll address each of these features. Let’s start from the beginning. The “T” and the “R” suggest that the study targets the regeneration of the thymus gland. The thymus gland plays a huge role in our immune system. It’s especially active and prominent from birth until puberty, after which it gradually decreases in activity, potency, and size. Nevertheless, it serves a pivotal role throughout our life in our body’s ability to fight infections and even cancer. The thymus gland deteriorates with time, and there is a distinct collapse of this gland between the early 50s and the late 60s, which manifests itself in the transformation of active cells into dormant fat cells. This decline goes hand in hand with a notable decrease in immune capabilities.
Another key factor in our immune system is bone marrow function. Bone marrow is a soft, fatty tissue inside bone cavities, and it is the primary site of new blood cell production. It contains immature cells called stem cells, which the body may convert into white blood cells, the active components of our immune system. Stem cells also play a crucial role in our body’s regeneration processes for different tissues. Bone marrow also helps in the removal of old cells from circulation. This brings us to the first “I” in the TRIIM study – Immunorestoration. The study targets the restoration and support of bone marrow function, which manifests itself in improved immune function.
So how do we achieve this?
The study targets thymus regeneration and Immunorestoration by prescribing a daily dosage of 0.015 mg/kg of HGH, equivalent to about 1.125 mg (or about 3.375 IU GH) for an average person weighing 75 kg. The fascinating effects of HGH on the thymus and the immune system were observed in previous experiments in rodents and dogs, and this was the first experiment that measured these effects in humans.
HGH treatment distinctly restores the active tissue in the thymus, as shown by repeated MRI scans. The active tissue in the thymus increased sharply, correlating with a decrease in dormant fat tissue. Similar effects were observed in the restoration of bone marrow function, indicated by higher active bone marrow tissue. Above all, the study followed and tested fundamental immune factors, showing marked improvements, along with different parameters of anti-cancer factors, inflammatory markers, and general blood chemistry, all showing significant improvements. Some blood chemistry parameters showed stability, indicating that GH treatment didn’t harm body functioning or cause any undesired side effects. For instance, it was suspected that GH, which increases IGF-1 levels, might increase cancer risks in tissues such as the prostate, but this treatment actually improved markers in this regard.
Another potential side effect of GH is its hyperglycemic effect, meaning HGH releases glucose into the circulation. This is part of its metabolic effects; increased glucose levels promote hyperinsulinemia, reduce insulin sensitivity, and may lead to type 2 diabetes. Generally, decreased insulin sensitivity and high serum glucose levels are directly correlated to multiple risk factors and must be controlled. This brings us to the final letters in the TRIIM abbreviation – Insulin Mitigation. The study achieved balanced glucose levels by combining HGH with metformin, which is designed to control glucose levels and increase insulin sensitivity, along with DHEA, which has been proven to support various health parameters in the aging population. Indeed, all of these parameters showed no decline thanks to this proven combination.
So what was observed beyond all of these, and most importantly, what did the epigenetic clocks show?
The study relied on four major epigenetic clocks that constitute the most important parameters in health and life expectancy. In all of the clocks and all participants, there were marked improvements. On average, over the one-year study, the average age reversal was 1.5 years. Considering that the participants aged one year in reality during the treatment, the treatment achieved an astonishing 2.5-year reversal in biological age. Interestingly and importantly, the biomarkers were tested monthly during the year of treatment, and the fastest reversal in aging parameters was observed between months 9 and 12, indicating that the longer the therapy, the steeper the improvement. Thus, HGH therapy has a cumulative effect. Furthermore, after the termination of the one-year therapy, there were some regression changes in some of the epigenetic clocks, meaning there was some regression from the age reversal achieved during the year of therapy, but only a partial one. However, in the most important clock – the GrimAge clock, which accurately predicts mortality, there was NO regression after six months of the treatment’s termination, proving the treatment’s long-term effectiveness after cessation.
It’s important to note that all participants were healthy subjects whose biological age was lower than their chronological age at the start, indicating that the treatment is effective for a healthy population in their post-middle-age prime years, making it a real anti-aging miracle.
Currently, HGH is prescribed only for severe conditions of HGH deficiency, such as dwarfism, and is not authorized by the FDA for anti-aging purposes. However, some anti-aging clinics do prescribe HGH, with treatment costs typically ranging from $750 to $2,000 per month. This is where sciroxxonline shines, providing the same service for a fraction of the cost.
We offer both our in-house compounded brands— the reputable Somastim and Novotrop—along with leading pharmaceutical brands such as Genotropin by Pfizer and Norditropin by Novo Nordisk.
Below, you can check multiple blood tests done by our customers as a testimony to the proven quality we always guarantee.both on our HGH and out Testosterone products

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Love the information and how this website always go above and beyond to assist with all questions and concerns. I have ordered from here before and nave nothing but good things to say. Keep it up
Love the information and how this website always go above and beyond to assist with all questions and concerns. I have ordered from here before and nave nothing but good things to say. Keep it up
Once again you guys went above and beyond by sharing this with everyone. Knowing about the studies and clinical trials gives us facts on exactly what HGH is and does, I’m sure there’s dozens of people who’ve been on the ropes and not sure about HGH for their long term safety so they never tried GH, well here you go for those of you who weren’t sure about your health and safety on HGH and you can breathe a big sigh of relief now and pull the trigger on stacking HGH with your gear! If I had the money God knows I’d be buying as much of this as possible but it’s just not feasible for me which sucks because I’ve always been curious about HGH and reading this makes me happy that facts are getting out there but bummed at the same time cuz I’m a broke bum LOL